HRID362048

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3301

Ethylenediamine

C2H8N2

结构：COc1ccc(CS[C@H]2C[C@@H](C(=O)O)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1

HCID15297071

未命名化合物

HCID140386401

未命名化合物

PRODUCTS

生成物

结构：O=C(N=CNCCNC(=O)[C@@H]1C[C@H](S)CN1C(=O)OCc1ccc([N+](=O)[O-])cc1)OCc1ccc([N+](=O)[O-])cc1

HCID178523919

未命名化合物

收率 27.2%

PROCEDURE

实验过程

Following a procedure similar to that described in Preparation 17, but using 850 mg of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 450 mg of ethylenediamine and 400 mg of N-(4-nitrobenzyloxycarbonyl)formamidine, 280 mg of the title compound were obtained as a powder.

WORKUP

后处理

customthat described in Preparation 17

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1180344f9b5c4f41bfa926eb835b138e
来源数据集: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05866564
来源说明: uspto-grants-1999_02

反应 SMILES

COC1C=CC(C[S:8][C@@H:9]2[CH2:13][N:12]([C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=3)=[O:15])[C@H:11]([C:27]([OH:29])=O)[CH2:10]2)=CC=1.[CH2:32]([NH2:35])[CH2:33][NH2:34].[N+:36]([C:39]1[CH:51]=[CH:50][C:42]([CH2:43][O:44][C:45]([NH:47][CH:48]=N)=[O:46])=[CH:41][CH:40]=1)([O-:38])=[O:37]>>[SH:8][C@@H:9]1[CH2:13][N:12]([C:14]([O:16][CH2:17][C:18]2[CH:19]=[CH:20][C:21]([N+:24]([O-:26])=[O:25])=[CH:22][CH:23]=2)=[O:15])[C@H:11]([C:27](=[O:29])[NH:34][CH2:33][CH2:32][NH:35][CH:48]=[N:47][C:45]([O:44][CH2:43][C:42]2[CH:50]=[CH:51][C:39]([N+:36]([O-:38])=[O:37])=[CH:40][CH:41]=2)=[O:46])[CH2:10]1