HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(N-Boc-amino)piperidine → (2S,4S)-4-Mercapto-2-[4-(N-4-nitrobenzyloxycarbonylacetimidoyl)aminopiperidin-1-ylcarbonyl)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Reactant | (2S,4S)-4-(4-methoxybenzyl)thio-1-(4-nitrobenzyloxycarbonyl)-L-proline | HCID 15297071 | — |
| Reactant | HCID 140352007 | HCID 140352007 | — |
| Product | (2S,4S)-4-Mercapto-2-[4-(N-4-nitrobenzyloxycarbonylacetimidoyl)aminopiperidin-1-ylcarbonyl)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine | HCID 178465420 | 97.3% |
Reaction Steps
Following a procedure similar to that described in Preparation 1, but using 446 mg of (2S,4S)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)-2-pyrrolidinecarboxylic acid, 220 mg of 4-t-butoxycarbonylaminopiperidine and 119 mg of N-(4-nitrobenzyloxycarbonyl)acetamidine, 307 mg of the title compound were obtained as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05866564 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-6b1190d03cfc4a028d2a39f76e5e8279 |
| Source note | uspto-grants-1999_02 |