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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 362092Generated: October 30, 2026

p-nitrobenzyl (1R,5R,6S)-2-(di-phenylphosphoryloxy)-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylate → HCID 178462318, compound

https://huagongshe.com/reaction/362092

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-nitrobenzyl (1R,5R,6S)-2-(di-phenylphosphoryloxy)-6-[(R)-1-hydroxyethyl]-1-methyl-carbapen-2-em-3-carboxylateHCID 15871605—
Reactant(2S,4S)-4-mercapto-1-methyl-2-(3-[N-(4-nitrobenzyloxycarbonyl)-N-formimidoylamino]azetidin-1-ylcarbonyl)pyrrolidineHCID 131720445—
ProductHCID 178462318HCID 1784623187.2%

Reaction Steps

A procedure similar to that described in Example 125 was repeated, but using 0.35 g of 4-nitrobenzyl (1R,5R,6S)-2-(diphenylphosphoryloxy)-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate (prepared as described in Preparation 123) and 0.22 g of (2S,4S)-4-mercapto-1-methyl-2-{3-[N-(4-nitrobenzyloxycarbonyl)-N-formimidoylamino]azetidin-1-ylcarbonyl}pyrrolidine (prepared as described in Preparation 118), to give 17 mg of the title compound as a powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05866564
Source datasetuspto-grants-1999_02
ORD IDord-c0d46350af884eb8908bce27a9810b3a
Source noteuspto-grants-1999_02