Trifluoroacetic acid → (4-nitrophenyl)methyl N-(piperazine-1-carboximidoyl)carbamate;bis(2,2,2-trifluoroacetic acid)

Participants

Reaction Steps

750 mg of 4-t-butoxycarbonyl-1-(4-nitrobenzyloxycarbonylamidino)piperazine [prepared as described in Preparation 92(b)] were dissolved in 12 ml of trifluoroacetic acid, and the resulting solution was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, and diethyl ether was added to the residue. The powder thus formed was washed three times with diethyl ether and then dried to obtain 1010 mg of the title compound, as a colorless powder.

Provenance & Evidence