Bromoacetonitrile → HCID 19939438, Verbindung

Beteiligte Stoffe

Reaktionsschritte

The alkylation of 5-n-butyl-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one (from Example 2, Step D) with bromoacetonitrile was carried out as described in Example 3, Step A. After work-up, the residue was flash chromatographed over silica gel (30 mL for 0.162 mmole, gradient elution using 0.5-2.0% MeOH/CH2Cl2 to give the desired compound in 58% yield, homogeneous by TLC in 2% MeOH/CH2Cl2, mass spectrum (FAB) m/e 657 (M+1)+.

Herkunft & Nachweise