HCID 22942118, compound → HCID 22942119, compound

Participants

Reaction Steps

A solution of 230 mg (0.223 mmol) of N-[N-[N-[N-[N-[3-(tert-butoxycarbonyl)propionyl]-O-tert-butyl-L-α-aspartyl]-O-tert-butyl-L-α-glutamyl]-2-methyl-L-phenylalanyl]-3-methyl-L-valyl]-3-cyclopentyl-L-alanine benzyl ester in 10 ml of dimethylformamidewas hydrogenated over 25 mg of 10% palladium/carbon for 3 hours. The catalyst was removed by filtration, the filtrate was evaporated and the residue was triturated with diethyl ether to give 206 mg of N-[N-[N-[N-[N-[3-(tert-butoxycarbonyl)propionyl]-O-tert-butyl-L-α-aspartyl]-O-tert-butyl-L-α-glutamyl]-2-methyl-L-phenylalanyl]-3-methyl-L-valyl]-3-cyclopentyl-L-alanine as a white solid; MS: m/e 944 [M+H].

Provenance & Evidence