Dichloromethane → HCID 22942064, compound

Participants

Reaction Steps

200 mg (0.18 mmol) of N2-[N-[N-[N-[N-(tert-butoxycarbonyl)-O-tert-butyl-L-α-aspartyl]-O-tert-butyl-L-α-glutamyl]-2-methyl-L-phenylalanyl]-3-methyl-L-valyl]-N1-[4-fluoro-1(RS)-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl]-L-leucinamide were dissolved in 4.75 ml of trifluoroacetic acid and 0.25 ml of water. 2 ml of dichloromethane were added and the solution was stirred at room temperature for 3 hours. The solution was diluted with toluene and evaporated. The residue was triturated with diethyl ether and the resulting solid was filtered off and dried to give 95 mg of 4-fluoro-1(RS)-[[N-[N-[N-[N-[N-(3-carboxypropionyl)-L-α-aspartyl]-L-α-glutamyl]-2-methyl-L-phenylalanyl]-3-methyl-L-valyl]-L-leucyl]amino]butylboronic acid; MS: m/e 849.4 [M+H-H2O]+.

Provenance & Evidence