1-Chloro-4-(3,4-difluorophenyl)-1-silacyclohexane → 4-(4-n-Heptyl-4-silacyclohexyl)-1,2-difluorobenzene

Participants

Reaction Steps

3.0 g (20 mmol) of 1-bromo-n-heptane was dropped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of THF to obtain Grignard reagent. This reagent was then dropped into a 50 ml THF solution of 4.9 g (20 mmol) of 4-(4-chloro -4-silacyclohexyl)-1,2-difluorobenzene to obtain 4-(4-n-heptyl -4-silacyclohexyl)-1,2-difluorobenzene. The product was a mixture of trans and cis isomers. They were separated by means of chromatography to obtain 5.3 g of the trans isomer (yield 93%).

Provenance & Evidence