Methanol → 2-[2-(2,2,3,3,4,4,4-Heptafluorobutoxy)ethoxy]ethan-1-ol
Reaction equation
O1CCCCC1[O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][C:15]([F:24])([F:23])[C:16]([F:22])([F:21])[C:17]([F:20])([F:19])[F:18].CO.S(=O)(=O)(O)O>O>[F:23][C:15]([F:24])([C:16]([F:21])([F:22])[C:17]([F:19])([F:20])[F:18])[CH2:14][O:13][CH2:12][CH2:11][O:10][CH2:9][CH2:8][OH:7]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Then, 17.4 g (0.047M) of 8,8,9,9,10,10,10-heptafluoro-3,6-dioxadecyl tetrahydropyranyl ether (purity: 99% or above), 35 ml of methanol, 18 ml of water and 2.2 ml of concentrated sulfuric acid were placed in a 100 ml-reaction vessel, followed by stirring for 2 hours at room temperature. The reaction mixture was poured into water and saturated with common salt. The saturated reaction mixture was subjected to extraction with ethyl acetate, washed with saturated common salt water and dried with anhydrous magnesium sulfate, followed by distilling-off of the solvent to obtain a residue. The residue was subjected to reduced-pressure distillation to obtain 6.4 g of 8,8,9,9,10,10,10-heptafluoro-3,6-dioxadecanol (b.p.: 86°-87° C./6 mmHg).
Workup
- extractionThe saturated reaction mixture was subjected to extraction with ethyl acetate
- washwashed with saturated common salt water
- dry with materialdried with anhydrous magnesium sulfate
- customto obtain a residue
- distillationThe residue was subjected to reduced-pressure distillation
Sources & evidence
- ORD record
- ord-e560c73791bf400ab12c7f151ea596ab
- Source dataset
- uspto-grants-1999_02
- Patent number
- US05868960
Reaction notes
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