反应详情

温度

150 °C

A mixture of 1F (14.5 g) and quinoline (50 ml) was treated with copper powder (4.57 g) and heated to 150° C. The reaction mixture is heated for 25 minutes at 150° C. and cooled to room temperature. The mixture was filtered and washed with water. Aqueous quinoline was acidified with 6N HCl (pH=2) and extracted with diethyl ether twice. The combined organic phases were washed with water and dried. The mixture was concentrated and the residue was chromatographed to yield a yellow liquid (8.74 g, 71%).

1. temperatureThe reaction mixture is heated for 25 minutes at 150° C.
2. temperaturecooled to room temperature
3. filtrationThe mixture was filtered
4. washwashed with water
5. extractionextracted with diethyl ether twice
6. washThe combined organic phases were washed with water
7. customdried
8. concentrationThe mixture was concentrated
9. customthe residue was chromatographed