Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Methylbutylamine → 4-[[(N-methyl-N-butylamino)methylene]amino]-3-pyridinol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Methylbutylamine | HCID 8068 | — |
| 반응물 | Ammonium Sulfate | HCID 6097028 | — |
| 반응물 | 4-[[(Dimethylamino)methylene]amino]-3-pyridinol | HCID 15380929 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-[[(N-methyl-N-butylamino)methylene]amino]-3-pyridinol | HCID 15380936 | 64.2% |
반응 단계
A mixture of 4-[[(dimethylamino)methylene]amino]-3-pyridinol (7.50 g), N-methylbutylamine (8.10 g), ammonium sulfate (0.600 g), and anhydrous toluene (25 mL) was heated at reflux under nitrogen for 2.25 hours. The solution was concentrated under reduced pressure and the crude product chromatographed on silica gel (10% methanol in dichloromethane) to afford 6.04 g of solid. Recrystallization from ethyl acetate/hexanes afforded 3.90 g of a crystalline material, m.p. 83°-85° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05869480 |
| 출처 데이터셋 | uspto-grants-1999_02 |
| ORD ID | ord-c9b102cdfcab4b2b80f20526c9c4c03c |
| 출처 메모 | uspto-grants-1999_02 |