Diethyl Ether → 4-[[(Dimethylamino)methylene]amino]-3-pyridinol N,N-diethylcarbamate

참여 물질

반응 단계

4-Amino-3-pyridinol N,N-diethylcarbamate (5.80 g) was refluxed for 30 minutes in 50 mL of N,N-dimethylformamide dimethyl acetal. At the end of this time the reaction mixture was concentrated under reduced pressure and the residue was purified by flash chromatography (5% Et3N/ethyl acetate) to give, after concentration of the product-containing fractions, 4.63 g of chromatographically pure product. An analytically pure material was obtained by recrystallizatin from Et2O, m.p. 67°-69° C.

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