HCID 178441625, compound → HCID 178441624, compound

HRID 362227Notes

Reaction equation

HRID 362227 reaction equation
C(C1N(CC2C=CC(C3C=CC=CC=3C3NN=NN=3)=CC=2)[C:9](=[O:29])C(CC(N2CCSCC2)=O)=C(C)N=1)CCC.[CH2:40]([C:44]1[N:49]([CH2:50][C:51]2[CH:56]=[CH:55][C:54]([C:57]3[CH:62]=[CH:61][CH:60]=[CH:59][C:58]=3[C:63]3[NH:67][N:66]=[N:65][N:64]=3)=[CH:53][CH:52]=2)[C:48](=[O:68])[C:47]([CH2:69][C:70]([N:72]2[CH2:77][CH2:76]N(C)[CH2:74][CH2:73]2)=[O:71])=[C:46]([CH3:79])[N:45]=1)[CH2:41][CH2:42][CH3:43].[CH2:80](C1N(CC2C=CC(C3C=CC=CC=3C3NN=NN=3)=CC=2)C(=O)C(CC(N2CCN(C(=O)C)CC2)=O)=C(C)N=1)CCC>>[CH2:40]([C:44]1[N:49]([CH2:50][C:51]2[CH:56]=[CH:55][C:54]([C:57]3[CH:62]=[CH:61][CH:60]=[CH:59][C:58]=3[C:63]3[NH:64][N:65]=[N:66][N:67]=3)=[CH:53][CH:52]=2)[C:48](=[O:68])[C:47]([CH2:69][C:70]([N:72]2[CH:77]([CH3:76])[CH2:9][O:29][CH2:74][CH:73]2[CH3:80])=[O:71])=[C:46]([CH3:79])[N:45]=1)[CH2:41][CH2:42][CH3:43]

Participants

4

Reactant 3

HCID 178441625HCID 178441625, compound2×HCID 178441626HCID 178441626, compound2×HCID 178441627HCID 178441627, compound2×

Product 1

HCID 178441624HCID 178441624, compound

Procedure

2-n-butyl-5-thiomorpholinocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-pyrimidin-4-(3H)-one (Compound 75) 2-n-butyl-5-(4'-methylpiperazinocarbonylmethyl)-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-pyrimidin-4-(3H)-one (Compound 76) 2-n-butyl-5-(4'-acetylpiperazinocarbonylmethyl)-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-pyrimidin-4-(3H)-one (Compound 77)

Sources & evidence

ORD record
ord-4db65066cffd42e79e527c625c6ef487
Source dataset
uspto-grants-1999_02
Patent number
US05869476

Reaction notes

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