HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 10640035, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 17beta-(Cyclopropyloxy)androst-5-en-3beta-ol | HCID 14882764 | — |
| Reactant | Jones' reagent | HCID 131709961 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 10640035 | HCID 10640035 | 57.2% |
Reaction Steps
A solution of 17β-cyclopropyloxy-androst-5-en-3β-ol (19.36 g, 58.9 mM) in acetone (1.9 L) is cooled to -3° C. and then treated with Jones reagent (20 ml). The excess reagent is decomposed with methanol. The solids are removed by filtration. The filtrate is concentrated to a green oil which is purified by flash chromatography on silica gel to give 17β-cyclopropyloxy-androst-4-en-3-one (11.0 g, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05869475 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-3a60d7df0c6b498b92d324fda3806d49 |
| Source note | uspto-grants-1999_02 |