Ethanol → 3-(Benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1-b]thiazole monohydrobromide dihydrate

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Reaction Steps

A mixture of 3-(2-bromoacetyl)benzo[b]thiophen (2.39 g), 2-imidazolidinethione (0.78 g), ethanol (60 ml) and acetic acid (40 ml) was heated under reflux for 18 hours then allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ether (2×50 ml), and dried in vacuo at ambient temperature to give 3-(benzo[b]thiophen-3-yl)-5,6-dihydroimidazo[2,1 -b]thiazole monohydrobromide dihydrate as a white solid (2.96 g), m.p. 239°-240° C.

Provenance & Evidence