Sodium Hydroxide → HCID 70284941, compound

HRID 362263Notes

Reaction equation

HRID 362263 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][C:7]([CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)([OH:10])[C:8](=[CH2:9])[C:4]=2[CH:3]=1.[OH-].[Na+]>ClCCl>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[S:6][CH2:9][CH:8]([C:7](=[O:10])[CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70284478HCID 70284478, compound

Product 1

HCID 70284941HCID 70284941, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 5-chloro-3-methylene-2-phenoxymethyl-2,3-dihydrobenzo[b]-thiophen-2-ol (16.9 g) in dichloromethane (250 ml) was shaken vigorously for a few seconds with 5M aqueous sodium hydroxide solution (150 ml), then the organic solution was separated, washed with water (150 ml), dried (MgSO4), and the solvent removed in vacuo to leave 1-(5-chloro-2,3-dihydrobenzo[b]thiophen-3-yl)-2-phenoxyethanone as a pink solid (16.4 g) which was used without further purification.

Workup

  1. customthe organic solution was separated
  2. washwashed with water (150 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-9e35c27a97f1484c816c2e9d40480353
Source dataset
uspto-grants-1999_02
Patent number
US05869492

Reaction notes

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