HCID 19939465, compound → HCID 178441926, compound

Participants

Reaction Steps

Deprotection of 5-n-butyl-2,4-dihydro-2-[3-(N-methyl-N-phenylcarbamoyloxy)propyl]-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one in 50% aqueous acetic acid was accomplished by the procedure of Example 3, Step B. After work-up, the residue was flash chromatographed over silica gel (35 mL for 0.13 mmole, gradient elution using 2-10% MeOH/CH2Cl2) to give the desired material as a foam in 68% yield, homogeneous by TLC in 10% MeOH/CH2Cl2, mass spectrum (FAB) m/e 567 (M+1)+.

Provenance & Evidence