Formamide → HCID 11558549, compound

Participants

Reaction Steps

4.78 g of 4-(4-fluorophenyl)-1-phenyl-2-amino-3-cyanopyrrole are heated at 180° C. with a spatula tipful of dimethylaminopyridine for 3.5 h in 50 ml of formamide under a nitrogen atmosphere. After cooling to RT, the mixture is treated with water and extracted 3 times with EA. The organic phases are washed with water, dried over Na2SO4 and concentrated. The residue is slurried with EA/ether and the crystals are filtered off. The crystals are suspended in hot ethanol and filtered off after cooling to RT. 5-(4-Fluorophenyl)-7-phenyl-4-aminopyrrolo[2,3-d]pyrimidine having a melting point of 202°-203° C. is obtained. 1H--NMR (d6 -DMSO): delta (ppm)=6.3 (br. s, 2H), 7.3-7.4 (m, 3H), 7.5-7.65 (m, 4H), 7.75 (s, 1H), 7.85 (d, 2H), 8.2 (s,1H).

Provenance & Evidence