Phenacyl bromide → HCID 53911750, compound

Participants

Reaction Steps

10 g of phenacyl bromide and 11 g of 3-benzyloxyaniline are stirred at 60° C. for 2 h in 100 ml of ethanol in the presence of 11.7 g of powdered Na2CO3. The mixture is then cooled and concentrated in an RE. The residue is partitioned between water and methylene chloride and the aqueous phase is extracted twice with methylene chloride. The combined organic phases are dried over Na2SO4 and concentrated. The residue is slurried with ether and the crystals are filtered off, 2'-(3-benzyloxyphenylamino)acetophenone being obtained.

Provenance & Evidence