HCID 54430137, compound → HCID 70202379, compound

Participants

Reaction Steps

0.5 g of 5-(4-benzyloxyphenyl)-7-[4-(2-(1-imidazolyl)ethoxy)phenyl]-4-aminopyrrolo[2,3-d]-pyrimidine is hydrogenated for 22 h in a hydrogen atmosphere at normal pressure and about 50° C. in 15 ml of THF in the presence of 0.1 g of 5% palladium/carbon. After filtration through Celite and crystallization by addition of ether, 5-(4-hydroxyphenyl)-7-[4-(2-(1-imidazolyl)ethoxy)phenyl]-4-aminopyrrolo[2,3-d]pyrimidine having an m.p. of 210°-212° C. is obtained.

Provenance & Evidence