Water → Ammonia

Participants

Reaction Steps

2 g of 5-(3-benzyloxyphenyl)-7-[3-(2-chloroethoxy)phenyl]-4-aminopyrrolo[2,3-d]pyrimidine (Ex. 153) and 0.46 g of imidazolyl sodium are heated to 50° C. in 45 ml of DMF and the mixture is stirred for 15 h. The mixture is then cooled to RT and treated with water, extracted 3 times with ethyl acetate and concentrated. After chromatography on silica gel (methylene chloride/methanol containing 5% of about 5N ammonia in methanol), 5-(3-benzyloxyphenyl)-7-[3-(2-(1-imidazolyl)ethoxy)phenyl]-4-aminopyrrolo[2,3-d]pyrimidine having an Rf=0.4 (silica gel, methylene chloride/methanol containing 5% of about 5N ammonia in methanol=9:1) is obtained.

Provenance & Evidence