Water → Ammonia

Participants

Reaction Steps

1.5 g of 5-(3-benzyloxyphenyl)-7-[3-(3-chloro-1-propoxy)phenyl]-4-aminopyrrolo[2,3-d]-pyrimidine and 0.33 g of imidazolyl sodium are heated to 50° C. in 30 ml of DMF and the mixture is stirred overnight. It is then cooled to RT, the solvent is stripped off in an RE and the mixture is treated with water, extracted 3 times with ethyl acetate and concentrated. 5-(3-benzyloxyphenyl)-7-[3-(3-(1-imidazolyl)propoxy)phenyl]-4-aminopyrrolo[2,3-d]-pyrimidine, (Rf=0.44, silica gel, methylene chloride/methanol containing 5% of about 5N ammonia in methanol 9:1) is obtained.

Provenance & Evidence