Water → HCID 70202784, compound

Participants

Reaction Steps

0.8 g of 5-(3-methoxyphenyl)-7-[3-(2-chloro-1-ethoxy)phenyl]-4-aminopyrrolo[2,3-d]-pyrimidine and 0.24 g of sodium imidazole are heated to 80° C. in 20 ml of DMF and stirred for 5 h. The mixture is then cooled to RT and treated with water, extracted 3 times with methylene chloride and concentrated. After chromatography on silica gel using methylene chloride/methanol 15:2 and crystallization from ether/methylene chloride, 5-(3-methoxy-phenyl)-7-[3-(2-(1-imidazolyl)ethoxy)phenyl]-4-aminopyrrolo[2,3-d]pyrimidine having an m.p. of 138°-140° C. is obtained.

Provenance & Evidence