反应详情

Deprotection of 2-[4-(benzyloxy)phenyl]-5-n-butyl-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one in 75% aqueous acetic acid was accomplished by the procedure of Example 5, Step C, except that the mixture was kept at 60° C. overnight. After work-up, the residue was flash chromatographed over silica gel (10 mL for 0.05 mmole; gradient elution with 2-5-10% methanol in CH2Cl2) to give a 43% yield of the title compound as a glassy solid, homogeneous by TLC in 10% MeOH/CH2Cl2 ; mass spectrum (FAB) m/e 558 (M+1)+.

1. customchromatographed over silica gel (10 mL for 0.05 mmole; gradient elution with 2-5-10% methanol in CH2Cl2)