[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl bromide → 4-[[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl]-2,4-dihydro-5-[(2-methylcyclopropyl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one

Participants

Reaction Steps

The title compound was prepared from 2,4-dihydro-5-[(2-methylcylopropyl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Step E) and [2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl bromide (from Example 12, Step D) according to the procedure of Example 13, Step A. The crude material was purified by flash chromatography over silica gel (gradient elution using 0.3-1.0% MeOH/CH2Cl2) to give a 64% yield of the desired material as a cream-colored solid, homogeneous by TLC in 2% MeOH/CH2Cl2 ; mass spectrum (FAB) m/e 599 (M+1)+ ; mp 128°-130° C.

Provenance & Evidence