Benzoic Acid → 4''-[3-(2-Methyl-cyclopropylmethyl)-5-oxo-1-(2-trifluoromethyl-phenyl)-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid benzoylamide

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Reaction Steps

The title compound was prepared from 2,4-dihydro-5-[(2-methylcyclopropyl)methyl]-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Step G) and benzoic acid according to the procedure of Example 43. The crude material was purified by flash chromatography over silica gel (gradient elution using 0.5-5.0% MeOH/CH2Cl2) to give a 64% of the desired material as a white solid, homogeneous by TLC (5% MeOH/CH2Cl2); mass spectrum (FAB) m/e 647 (M+1)+ ; mp 123°-125° C.

Provenance & Evidence