Ethanol → HCID 74011442, compound

Participants

Reaction Conditions

Reaction Steps

10 ml of ethanol are added to a solution of 1 g (2.56 mmol) of phenylmethyl γ-oxo-α(R,S)-(phenylmethyl)-5,6-dihydro-4H-furo[3,4-c]pyrrole-5-butanoate in 10 ml of tetrahydrofuran followed, at 0° C., by a solution of 0.308 g (7.7 mmol) of sodium hydroxide in 10 ml of water. The mixture is stirred for 2 h at 0° C., and then for 2 h at room temperature. The solution obtained is concentrated, 30 ml of water are added and the solution is washed with twice 35 ml of diethyl ether. The aqueous phase is cooled, and then a 2M solution of hydrochloric acid is added to pH 2. The precipitate formed is filtered, it is washed with twice 20 ml of water and it is dried under vacuum. 0.47 g of a white solid is obtained. Yield 61%.

Provenance & Evidence