反应详情

Silver tetrafluoroborate (1,168 mg) was suspended in 6 ml of dimethyl sulfoxide, 1,230 mg of 7-Bromomethyl-2-naphthalenecarbonitrile was added to the suspension, and the mixture was stirred at room temperature for 14 hours. The reaction solution was filtered, water was added to the mother liquid, and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulfate, and then evaporated. The resulting residue was purified by silica gel column chromatography using a mixture of hexane and ethyl acetate as the eluent to give 543 mg of 7-formyl-2-naphthalenecarbonitrile in the form of white solid.

1. filtrationThe reaction solution was filtered
2. additionwater was added to the mother liquid
3. extractionthe mixture was extracted with ethyl acetate
4. washThe extract was washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated
7. customThe resulting residue was purified by silica gel column chromatography
8. additiona mixture of hexane and ethyl acetate as the eluent