HRID362533

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7748

Ethyl bromoacetate

C4H7BrO2

结构：CC(C)(C)OC(=O)NS(=O)(=O)N(Cc1ccc2ccc(C#N)cc2c1)c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1

HCID15392237

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CN(C(=O)OC(C)(C)C)S(=O)(=O)N(Cc1ccc2ccc(C#N)cc2c1)c1ccc(OC2CCN(C(=O)OC(C)(C)C)CC2)cc1

HCID15392245

未命名化合物

PROCEDURE

实验过程

Starting compound: t-butyl N-[N-[4-[(1-t-butoxycarbonyl-4-piperidyl)oxy]phenyl]-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl]carbamate, ethyl bromoacetate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1a1591d9121c4c6c882d06d8b9264fbd
来源数据集: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05869501
来源说明: uspto-grants-1999_02

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]([CH2:33][C:34]3[CH:43]=[CH:42][C:41]4[C:36](=[CH:37][C:38]([C:44]#[N:45])=[CH:39][CH:40]=4)[CH:35]=3)[S:22]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])(=[O:24])=[O:23])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:47][C:48]([O:50][CH2:51][CH3:52])=[O:49]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]([CH2:33][C:34]3[CH:43]=[CH:42][C:41]4[C:36](=[CH:37][C:38]([C:44]#[N:45])=[CH:39][CH:40]=4)[CH:35]=3)[S:22]([N:25]([C:26]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:32])[CH2:47][C:48]([O:50][CH2:51][CH3:52])=[O:49])(=[O:24])=[O:23])=[CH:17][CH:16]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]