反应详情

A solution of 1-benzyl-3-carbomethoxy-4-piperidone (1.0 g, 4.0 mmol) in THF (10 mL) was treated with 0.5M potassium bis(trimethylsilyl)amide in toluene (9.6 mL, 4.8 mmol) for 15 min, followed by the addition of benzyl bromide (1.2 g, 4.8 mmol). After 2 h, the reaction mixture was quenched with sat. NH4Cl and extracted with ether. The combined organic layers were washed with brine, dried with MgSO4 and concentrated. The product was purified by silica gel chromatography eluting with 4:1 hexane-EtOAc to give 3-carbomethoxy-1,3-dibenzyl-4-piperidone (0.61 g) as a light yellow oil.

1. customthe reaction mixture was quenched with sat. NH4Cl
2. extractionextracted with ether
3. washThe combined organic layers were washed with brine
4. dry with materialdried with MgSO4
5. concentrationconcentrated
6. customThe product was purified by silica gel chromatography
7. washeluting with 4:1 hexane-EtOAc