HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1,3-Dibenzylpiperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Carbomethoxy-1,3-dibenzyl-4-piperidone | HCID 54232857 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1,3-Dibenzylpiperidin-4-one | HCID 23003659 | 62.3% |
Reaction Steps
A solution of 3-carbomethoxy-1,3-dibenzyl-4-piperidone (0.61 g, 1.78 mmol), MeOH (10 mL) and 5M HCl aq. (25 mL, 125 mmol) was refluxed overnight. The reaction mixture was concentrated and chromatographed (silica gel, eluting with 4:1 hexane-EtOAc) to give 1,3-dibenzyl-4-piperidone (0.31 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05869488 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-f145b1af83a546b4a75ea44357d436b1 |
| Source note | uspto-grants-1999_02 |