[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl bromide → 5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-2-[5-(carbomethoxy)-2-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Participants

Reaction Steps

By the procedure of Example 13, Step A, 5-n-butyl-2-[5-(carbomethoxy)-2-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (from Step A) was alkylated with [2'-(N-t-butylsulfamoyl)biphenyl- 4-yl]methyl bromide (from Example 12, Step D). Flash chromatography of the crude product on silica gel (gradient elution with 0.5-5.0% MeOH in CH2Cl2) gave an 85% yield of the title compound as a white solid, mp 65°-67° C., homogeneous by TLC (98:2 CH2Cl2 --MeOH), mass spectrum (FAB) m/e 555 [M-(t-Bu)]+.

Provenance & Evidence