HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (R)-2-Amino-9-(2-stearoyloxymethyl-4-(L-valyloxy)butyl)purine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 54149671 | HCID 54149671 | — |
| Product | (R)-2-Amino-9-(2-stearoyloxymethyl-4-(L-valyloxy)butyl)purine | HCID 54535483 | 124.4% |
Reaction Steps
(R)-2-Amino-9-(2-Stearoyloxymethyl-4-(N-tert-butoxycarbonyl-L-valyloxy)butyl)purine (180 mg, 0.26 mmole) was treated with trifluoroacetic acid (5 ml) at 0° C. for 40 min. It was then evaporated in vacuo and coevaporated successively with toluene and methanol. The residue was freeze-dried overnight to give 195 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05869493 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-2edfaba530cb4d359a9f2147c43894fe |
| Source note | uspto-grants-1999_02 |