HCID 17892747, compound → HCID 17853971, compound

HRID 362615Notes

Reaction equation

HRID 362615 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[C:19]([C:21]3[N:22]([CH:33]4[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]4)[CH:23]=[C:24]([C:26]4[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=4)[N:25]=3)[CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd]>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]2[N:20]=[C:19]([C:21]3[N:22]([CH:33]4[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]4)[CH:23]=[C:24]([C:26]4[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=4)[N:25]=3)[CH:18]=[CH:17][N:16]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 1

HCID 17892747HCID 17892747, compound

Product 1

HCID 17853971HCID 17853971, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 5-[(2-(1-benzyl-4-piperidinylamino)pyrimidin-4-yl]-4-(4-fluorophenyl)-1-(1-methylpiperdin-4-yl)imidazole (0.50 g, 0.95 mmol) and 10% palladium on carbon (10%) was stirred under an atmosphere of H2 for 18 h. The catalyst was removed by filtration and the filtrate was evaporated under reduced pressure. The residue was recrystallized from EtOAc/hexanes to afford the title compound as a white solid; yield 0.98 g (24%): mp=201°-203° C.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated under reduced pressure
  3. customThe residue was recrystallized from EtOAc/hexanes

Sources & evidence

ORD record
ord-fd8c30ce4cd14eae8fd6f8976d7fa80a
Source dataset
uspto-grants-1999_02
Patent number
US05869660

Reaction notes

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