Sodium Hydroxide → HCID 15767493, compound

HRID 362642Notes

Reaction equation

HRID 362642 reaction equation
[NH2:1][CH:2]1[N:6]([C:7]2[CH:11]=[C:10]([O:12][CH:13]([F:15])[F:14])[N:9]([CH3:16])[N:8]=2)[N:5]=[CH:4][C:3]1(C1C=CNN=1)[C:17]([O:19]CC)=[O:18].[OH-].[Na+]>C(O)C>[NH2:1][C:2]1[N:6]([C:7]2[CH:11]=[C:10]([O:12][CH:13]([F:14])[F:15])[N:9]([CH3:16])[N:8]=2)[N:5]=[CH:4][C:3]=1[C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178468431HCID 178468431, compound

Product 1

HCID 15767493HCID 15767493, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

18.9 g (0.06 mol) Ethyl 5-Amino-1-(5-difluoromethoxy-1-methyl-3-pyrazolyl)-4-pyrazolyl-4-pyrazolecarboxylate was dissolved in 150 ml 50% ethanol and treated with 15 ml 45% caustic soda. The mixture was heated for 2 hours at 80° C., the ethanol distilled, the residue treated with ice-water and acidified with concentrated hydrochloric acid. The residue was removed by suction filtration, washed with water and dried in vacuo at 75° C.

Workup

  1. distillationthe ethanol distilled
  2. additionthe residue treated with ice-water
  3. customThe residue was removed by suction filtration
  4. washwashed with water
  5. customdried in vacuo at 75° C.

Sources & evidence

ORD record
ord-eedf3f8d93b14de3a84627f4b596bc3a
Source dataset
uspto-grants-1999_02
Patent number
US05869686

Reaction notes

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