Ammonia → 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxamide

HRID 362650Notes

Reaction equation

HRID 362650 reaction equation
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)=O.[NH3:15]>>[C:3]([C:5]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)(=[O:2])[NH2:15]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 54319416Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate

Product 1

HCID 537319905-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxamide

Procedure

80.6 g (0.39 mol) 3-Methoxycarbonyl-5-difluoromethoxy-1-methylpyrazole and 300 ml aqueous ammonia (33%) was stirred for one hour under reflux. The reaction solution was cooled, the precipitate suction filtered off and washed with water and diisopropyl ether.

Workup

  1. temperatureunder reflux
  2. temperatureThe reaction solution was cooled
  3. filtrationthe precipitate suction filtered off
  4. washwashed with water and diisopropyl ether

Sources & evidence

ORD record
ord-0e90a0857ab446fe856fae9be5773a54
Source dataset
uspto-grants-1999_02
Patent number
US05869686

Reaction notes

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