Sulfuryl chloride → 3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

HRID 362653Notes

Reaction equation

HRID 362653 reaction equation
[F:1][CH:2]([F:14])[O:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1.S(Cl)([Cl:18])(=O)=O>C(Cl)Cl>[Cl:18][C:5]1[C:6]([C:10]([O:12][CH3:13])=[O:11])=[N:7][N:8]([CH3:9])[C:4]=1[O:3][CH:2]([F:1])[F:14]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 54319416Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate

Product 1

HCID 537351233-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.1 g (10 mmol) 5-Difluoromethoxy-3-methoxycarbonyl-1-methylpyrazole, dissolved in 30 ml methylene chloride, was treated with 1.35 g (10 mmol) sulfuryl chloride and the mixture stirred at room temperature for 10 minutes. It was then concentrated and the residue recrystallised from diisopropyl ether/ethyl acetate.

Workup

  1. concentrationIt was then concentrated
  2. customthe residue recrystallised from diisopropyl ether/ethyl acetate

Sources & evidence

ORD record
ord-0730b82069b94c9d8e03c745348d8f04
Source dataset
uspto-grants-1999_02
Patent number
US05869686

Reaction notes

Loading…