Sodium Hydroxide → HCID 54153912, compound

HRID 362658Notes

Reaction equation

HRID 362658 reaction equation
[F:1][CH:2]([F:21])[O:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([N:10]2[C:14]([CH3:15])=[C:13]([C:16]([O:18]CC)=[O:17])[CH:12]=[N:11]2)[CH:5]=1.[OH-].[Na+]>C(O)C>[F:21][CH:2]([F:1])[O:3][C:4]1[N:8]([CH3:9])[N:7]=[C:6]([N:10]2[C:14]([CH3:15])=[C:13]([C:16]([OH:18])=[O:17])[CH:12]=[N:11]2)[CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53681002HCID 53681002, compound

Product 1

HCID 54153912HCID 54153912, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1.25 g (4.16 mmol) Ethyl 1-(5-difluoromethoxy-1-methyl-3-pyrazolyl)-5-methyl-4-pyrazolecarboxylate, 20 ml ethanol and 0.97 ml aqueous sodium hydroxide (45%) was stirred for 1 hour at 80° C. The reaction solution was concentrated to a half and acidified with hydrochloric acid (37%). The precipitate was suction filtered off, washed with water and dried.

Workup

  1. concentrationThe reaction solution was concentrated to a half
  2. filtrationfiltered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-0c558d67663c42fcb540f21416a4eb33
Source dataset
uspto-grants-1999_02
Patent number
US05869686

Reaction notes

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