反应详情

温度

50 °C

5.55 g (33.0 mmol) 3-amino-4-cyano-1-methyl-5-methylmercaptopyrazole heated with 50 ml 32% caustic soda at boiling for 24 hours. The reaction mixture was cooled, made slightly acidic with aqueous sodium hydrogen phosphate, heated for 8 hours at 50° C. and extracted with ethyl acetate. The organic phase was dried over sodium sulfate, concentrated and the residue purified by silica gel chromatography (hexane/ethyl acetate 1:1).

1. temperatureThe reaction mixture was cooled
2. extractionextracted with ethyl acetate
3. dry with materialThe organic phase was dried over sodium sulfate
4. concentrationconcentrated
5. customthe residue purified by silica gel chromatography (hexane/ethyl acetate 1:1)