Hydrochloric Acid → HCID 131721121, compound

Participants

Reaction Conditions

Reaction Steps

N-[(t-Butyloxycarbonyl)-pyrrolidin-2(S)-ylmethyl]-3(S)-ethyl-proline-N-(3-chlorophenylmethyl) amide (Example 1, Step H) (0.175 g, 0.39 mmol) was dissolved in EtOAc (15 mL), cooled to -20° C. and saturated with HCl gas. The solution was stirred at 0° C. for 1 h, then at 25° C. for 1 h, then concentrated to dryness to give pyrrolidin-2(S)-ylmethyl!-3(S)-ethyl-proline-N-(3-chlorophenylmethyl) amide which was used without further purification.

Provenance & Evidence