HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → 4-Methoxycarbonyl-4-phenylpiperidine p-toluenesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 4-Piperidinecarboxylic acid, 4-phenyl-, 4-methylbenzenesulfonate (1:1) | HCID 2723657 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Methoxycarbonyl-4-phenylpiperidine p-toluenesulfonate | HCID 21699518 | 453.8% |
Reaction Steps
1 g of p-toluenesulfonic acid monohydrate is added to a solution of 10 g of 4-carboxy-4-phenylpiperidine p-toluenesulfonate in 300 ml of MeOH and the reaction mixture is refluxed for 3 days. It is concentrated under vacuum, the residue is taken up with acetone, and ether is added until precipitation occurs. 9.34 g of the expected product are obtained after wringing of the precipitate formed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05869663 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-2381d59a39d84887840dbd04ed733abe |
| Source note | uspto-grants-1999_02 |