HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Amino-5-chloro-2,3-dihydro-7-benzofurancarbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid | HCID 10632401 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-Amino-5-chloro-2,3-dihydro-7-benzofurancarbonyl chloride | HCID 53980070 | 100% |
Reaction Steps
A mixture of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic acid (4.3 g) in thionyl chloride (100 ml) and CHCl3 (200 ml) was stirred and refluxed for 2 hours. The mixture was cooled and the solvent was evaporated. Toluene was added and evaporated again, yielding 4.8 g of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarbonyl chloride (100% crude residue) (intermediate 7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05872131 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-1043e9bb59bb4746884d7d3f2f8ad2eb |
| Source note | uspto-grants-1999_02 |