HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Fluorophenyl)-2-propenoic acid → 3-(4-Fluorophenyl)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Fluorophenyl)-2-propenoic acid | HCID 98070 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(4-Fluorophenyl)propionic acid | HCID 136302 | 91% |
Reaction Steps
A mixture of 4-fluorocinnamic acid (300.0 g, 1.8 mol, Aldrich) and 5% palladium on carbon (9.0 g) in ethanol (3 L) was hydrogenated at atmospheric pressure and room temperature for 4.5 h. The mixture was filtered through Celite (diatomaceous earth) and the filtrate was concentrated in vacuo to give 275.1 g (91%) of 3-(4-fluorophenyl)propionic acid as a white solid: m.p., 86°-88° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05872118 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-9fffec0f198b4e048795124dd3fd9a26 |
| Source note | uspto-grants-1999_02 |