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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 362804Generated: October 25, 2026

3-(4-Fluorophenyl)-2-propenoic acid → 3-(4-Fluorophenyl)propionic acid

https://huagongshe.com/reaction/362804

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Fluorophenyl)-2-propenoic acidHCID 98070—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
Product3-(4-Fluorophenyl)propionic acidHCID 13630291%

Reaction Steps

A mixture of 4-fluorocinnamic acid (300.0 g, 1.8 mol, Aldrich) and 5% palladium on carbon (9.0 g) in ethanol (3 L) was hydrogenated at atmospheric pressure and room temperature for 4.5 h. The mixture was filtered through Celite (diatomaceous earth) and the filtrate was concentrated in vacuo to give 275.1 g (91%) of 3-(4-fluorophenyl)propionic acid as a white solid: m.p., 86°-88° C.;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05872118
Source datasetuspto-grants-1999_02
ORD IDord-9fffec0f198b4e048795124dd3fd9a26
Source noteuspto-grants-1999_02