HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(4-Fluorophenyl)propionyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(4-Fluorophenyl)propionic acid | HCID 136302 | — |
| Product | 3-(4-Fluorophenyl)propionyl chloride | HCID 21964258 | 96.3% |
Reaction Steps
A mixture of 3-(4-fluorophenyl)propionic acid (275.1 g, 1.6 mol) and thionyl chloride (300 mL, 4.1 mol) was heated to reflux for 3 h, cooled to room temperature and distilled under aspirator vacuum to give 287.6 g (96%) of 3-(4-fluorophenyl)propionyl chloride as a pale pink oil, b.p., 120°-122° C./15 mm Hg:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05872118 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-b35a9893a28d48c2b269c358caf2e0f2 |
| Source note | uspto-grants-1999_02 |