HCID 21927967, compound → 2-(6-Fluoro-3-oxo-1-indanyl)acetic acid

Participants

Reaction Conditions

Reaction Steps

Polyphosphoric acid (39.6 g, Aldrich) and 3-(3-fluorophenyl)glutaric acid (6.6 g, 0.0292 mol) were combined and the mixture heated with an oil bath at 120° C. for 10 min. The now red solution was cooled to approximately 60° C. and water (approximately 100 ml) was added dropwise, with efficient stirring. The resulting precipitate was collected and washed with water. Recrystallization from dichloromethane and hexanes gave 5.3 g (87%) of 2-(6-fluoro-3-oxo-1-indanyl)acetic acid: m.p., 150°-151° C.;

Provenance & Evidence