Potassium Sodium Tartrate → HCID 67763856, compound

Participants

Reaction Steps

A solution of AlCl3 (1.0 g, 7.5 mmol) in dry ether (10 ml) was added rapidly to a solution of LiAlH4 (0.5 g, 13.2 mmol) in dry ether (13 ml). After 5 minutes, a suspension of 2-bromo-11-cyano-6,11-dihydrodibenz[b,e]oxepin (2.0 g, 6.7 mmol) in dry ether (100 ml) was added to the mixture of hydride. The reaction mixture was stirred for 4.5 hours. Water and Rochelle Salt were added to the reaction mixture. The mixture was poured into ether. The organic layer was dried (MgSO4) and concentrated. The residue was purified by column chromatography on silica gel to give 11-aminomethyl-2-bromo-6,11-dihydrodibenz[b,e]oxepin (48.9%).

Provenance & Evidence