Ethanol → HCID 67763789, compound

Participants

Reaction Steps

Step 2): A suspension of 11-(1,4-dioxa-8-azaspiro[4,5]decane-8-yl)-2-bromo-6,11-dihydrodibenz[b,e]oxepin (5.5 g, 13.2 mmol) in 4N HCl was heated at 60°-70° C. for 30 minutes. Then ethanol was added to the mixture. The mixture was heated at 60°-70° C. for 1.5 hours. After ethanol was evaporated, the reaction mixture was made alkaline with 50% NaOH solution, then extracted with ethyl acetate and chloroform. The organic layer was washed with water, dried (MgSO4) and concentrated to give 11-(4-oxopiperidin-1-yl)-2-bromo-6,11-dihydrodibenz[b,e]oxepin (100%): mp 196°-200° C.

Provenance & Evidence