1-Bromo-2-Chloroethane → HCID 67597224, compound

Participants

Reaction Conditions

Reaction Steps

Step 1): 1-Bromo-2-chloroethane (10.0 g, 0.07 mmol) was added by portions to a solution of 1,4-dioxa-8-azaspiro[4,5]decane (1.0 g, 7.0 mmol) and Et3N (0.7 g, 7.0 mmol) in acetonitrile (10 ml) at 0° C. The mixture was stirred at 0° C. for 48 hours, poured into ethyl acetate and washed with water. The organic layer was dried (MgSO4) and concentrated to give 8-(2-chloroetyl)-1,4-dioxa-8-azaspiro-[4,5]decane (0.914 g, 63.5%) as a solid product.

Provenance & Evidence