Aluminium lithium hydride → 4-(N-methylamino)methyl-1-diphenylmethylpiperidine

HRID 362904Notes

Reaction equation

HRID 362904 reaction equation
[CH:1]([NH:3][CH2:4][CH:5]1[CH2:10][CH2:9][N:8]([CH:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH3:1][NH:3][CH2:4][CH:5]1[CH2:10][CH2:9][N:8]([CH:11]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 539859804-(N-formylamino)methyl-1-diphenylmethylpiperidine

Product 1

HCID 537192494-(N-methylamino)methyl-1-diphenylmethylpiperidineYield 100%

Procedure

Step 2): In a similar manner to that of Preparation 1 step 2), 4-(N-formylamino)methyl-1-diphenylmethylpiperidine was reduced by LiAlH4 to give 4-(N-methylamino)methyl-1-diphenylmethylpiperidine; yield 100%.

Sources & evidence

ORD record
ord-0ae05bb9987943fcad3ff42aa67332ee
Source dataset
uspto-grants-1999_02
Patent number
US05872115

Reaction notes

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