HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 5-dimethylamino-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 5-fluoro-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide | HCID 67595215 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-dimethylamino-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide | HCID 54209121 | — |
Reaction Steps
Step 4): A mixture of 5-fluoro-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)-methyl]benzamide (13.4 g, 30 mmol) and 2.0M MeOH solution of dimethylamine (45 ml, 90 mmol) in THF (100 ml) was refluxed for 22 hours. The resulting solution was evaporated to give 5-dimethylamino-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide as yellow powders, 14.1 g (99.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05872115 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-3d8b4dfe5fb443f289fe8ac07466a7e2 |
| Source note | uspto-grants-1999_02 |